Comparison of Oral with Intranasal Treatment of Hyposmia
We have demonstrated efficacy of both oral and intranasal theophylline to treat smell loss (hyposmia). While both modes of treatment are effective, treatment methods are quite different for each mode of drug administration.
Oral Theophylline: 200-800 mg of theophylline is necessary to improve hyposmia
Oral Theophylline: treatment requires continual drug use for 2-8 months in order to improve hyposmia
Oral Theophylline: serum drug levels of 2-20 mg/dL are necessary to improve hyposmia
Oral Theophylline: drug administration can induce multiple and severe side effects – tachycardia, cardiac palpitations, gastrointestinal upset, sleep disturbances, excitability.
Based upon these observations treatment with intranasal theophylline is superior to treatment with oral theophylline.